By: Kate Noonan for This Organic Girl
Kate Noonan, Molecular Biologist and Cosmetic Chemist, is a voted-in member of the Society of Cosmetic Chemists, the Society for Investigative Dermatology and the American Society for Microbiology.
IN THIS POST:
A note from Lisa
This is a resource that I’ve wanted to make available to the TOG community for a long time now. To be honest, my hesitation in publishing a page like this was equal parts fear in taking on such a big project, as well as subscribing to fear-based messaging. My hope is that you use this list as a tool to make informed choices rather than inspire limitations, fear and additional stress. For this reason, we’ve abbreviated this list to just a few ingredients—ones we believe to be either the most prevalent and/or the most egregious.
In a perfect world, you would be able to pick up a label, see one of these and then be able to ask the right questions.
I also want to say thanks to molecular biologist and cosmetic chemist Kate Noonan. Kate has worked with TOG for several years now, reviewing posts and helping with research, so you will see her name on the blog here and there. When I approached Kate about putting this list together, she didn’t even hesitate. She is just as passionate about ethical beauty as we are and has so much insight into the world of formulating, regulation and the effect of ingredients on the body.
As part of our TOG Credo, we strive to avoid these ingredients in products we test and encourage you to say NO THANKS to them too.
One last thing…BOOKMARK THIS ISH! lol.
A note from Kate
The U.S. Department of Health and Human Services (DHHS), the U.S. National Institutes of Health (NIH), the U.S. National Cancer Institute (NCI), the U.S. National Toxicology Program (NTP), the State of California, the World Health Organization’s International Agency for Research on Cancer (WHO, IARC), and expert university scientists have classified each of the following chemicals in U.S. beauty products as either confirmed human carcinogens, anticipated human carcinogens or toxicants. Dr. Leonardo Trasande, MD, Research Vice-Chair in the Department of Pediatrics at NYU Langone Hospital, advises consumers to avoid these listed chemicals entirely. “The dose does not necessarily make the poison,” he says. “Each day we find new examples of chemicals that have the greatest effects at the lowest levels of exposure.”
Glossary of Terms
- ALARA Principle: “As low as reasonably achievable”
- DHHS: U.S. Department of Health and Human Services
- EU SCC: European Union’s Standard Contractual Clauses
- IARC: World Health Organization’s International Agency for Research on Cancer
- NIH: U.S. National Institutes of Health
- NCI: U.S. National Cancer Institute
- NTP: U.S. National Toxicology Program
- PPM: Parts per million
- Prop 65: Proposition 65 of California
- WHO: World Health Organization
1,4-dioxane is “reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity,” according to the U.S. NTP. It’s present in ethoxylated ingredients like sodium laureth sulfate (SLS), polysorbate 60 and polysorbate 80 at up to ~378 parts per million (ppm) (1, 2). Since 1,4-dioxane is in the most hazardous category of carcinogens, the in vivo-confirmed “genotoxic category,” and it can induce DNA mutations at very low levels, there is no acceptable level of exposure. The NIH and EFSA recommend following the ALARA Principle (as low as reasonably achievable), meaning one should avoid exposure to any dose.
Acetaldehyde is a carcinogenic petrochemical-derived perfume (fragrance note). Perfumes in the “aldehyde” scent category are higher in acetaldehyde concentration. U.S. Department of Health and Human Services (DHHS) says acetaldehyde is “reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity (3).”
Acetone is a neurotoxic and flammable solvent used in nail polish remover. If your eyes are burning at a nail salon, take that as a cue to leave because there is a risk of nerve damage based on evidence from human nerve conduction velocity tests (4).
Acetonitrile is a solvent found in cheap nail polish remover that turns into cyanide following skin absorption and inhalation. The EU SCC has banned its use in cosmetics and nail products due to toxicity and carcinogenicity experiments (5).
“Carbomer” and “Acrylate crosspolymer” are crosslinked polymers of acrylic acid with unreacted neurotoxic acrylic acid and residual benzene solvent. Products made with carbomer and acrylates regularly contain more than 2 ppm benzene, according to the FDA. “The maximum allowable amount of benzene in workroom air during an 8-hour workday, 40-hour workweek is 1 ppm,” according to the CDC’s Agency for Toxic Substances and Disease Registry (ATSDR). We would like to see companies show test results for the level of benzene in products that use carbomer and acrylates, since they’re required by the FDA to perform this test anyway.
Aluminum chlorohydrate (ACh, [Al2(OH)5Cl, 2H2O])
Found in antiperspirants, this form of aluminum is a DNA-reactive carcinogen and neurotoxicant with high transdermal skin absorption following shaving, chemical, or manual exfoliation (6, 7). Systemic absorption of aluminum salts from antiperspirants has led to hyperaluminemia, which causes bone pain and fatigue (8). The European Food Safety Authority (EFSA) set a tolerable weekly intake (TWI) of 1 mg/kg body weight per week, which can be exceeded with dermal application and consumption of processed foods (9).
Aminomethyl Propanol (AMP)
Found in cleansers and toners, AMP causes the formation of carcinogenic nitrosamines in cosmetics (including N-nitrosodimethylamine, N-nitrosodiethylamine, N-nitrosodi-n-propylamine, N-nitrosomorpholine, and N-nitrosopyrrolidine). U.S. Department of Health and Human Services says nitrosamines formed by AMP are “reasonably anticipated to be human carcinogens based on sufficient evidence of carcinogenicity (10).”
Benzalkonium Chloride (BAC)
Some moisturizers and cleansers use this quaternary ammonium compound in their preservative system. Do not use products with BAC near the eyes after an eye procedure because long-term eye damage may occur (highly toxic to the corneal endothelial cells) (14).
Butylated Hydroxyanisole (BHA)
BHA is a carcinogenic synthetic antioxidant found in personal care products and certain non-organic foods. The U.S. DHHS/NTP says it’s “reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity (15).” Also Prop. 65 of California has it listed as “causing: cancer” (following IARC research) (16).
Butylated hydroxytoluene (BHT)
Butylated hydroxytoluene (BHT), a carcinogen and tumor-promoter, is used in some cosmetics as a synthetic antioxidant for preservation (17). Proposition 65 of California does not have it listed, but evidence of carcinogenicity is noted with: positive result in the mouse lymphoma assay; and positive results in the “clastogenic and chromosomal aberration assays in mammalian cells—human embryonic lung cells (positive for anaphase chromosomes), CHO (positive) (18).”
Bisphenol A (BPA)
BPA in some skincare aluminum tube epoxy lining is a probable human carcinogen, tumor promoter, and it worsens cancer progression, based on extensive in vivo and epidemiological evidence. “Studies using in vitro cell lines, rodent models, and epidemiological analysis have convincingly shown the increasing susceptibility to cancer at doses below the oral reference dose set by the Environmental Protection Agency for BPA (19, 20, 21).”
The underlying mechanisms are: direct genotoxic ability to break double-strand DNA and activation of G-Protein-Coupled Estrogen Receptor (GPER), which, “promotes proliferation, invasion and migration of breast cancer cells by regulating the miR-124/CD151 pathway (22, 23, 24, 25).” Even at super low doses, BPA causes chemotherapy resistance to every drug used to treat cancer: “doxorubicin, cisplatin, carboplatin, tamoxifen (TAM), bevacizumab, PARP inhibitors, vinblastine and other drugs both in vitro and in vivo (23).”
Tufts University in Boston published a study saying, “Based on the definitions of ‘carcinogen’ put forth by the IARC and the National Toxicology Program (NTP), we propose that BPA may be reasonably anticipated to be a human carcinogen in the breast and prostate due to its tumor promoting properties (23).” Prop. 65 of California lists BPA as “causing: developmental toxicity, female reproductive toxicity (26).”
A fragrance ingredient that lends a “sweet” note, but causes abnormal red blood cell count when exposure is routine. Lower exposure in cosmetics causes skin irritation, while low occupational exposure (2.91 mg/m3 or 0.59 ppm), for fragrance industry and beverage packaging/printing workers is much more damaging (27, 28).
A synthetic preservative that is very toxic to eye cells, a strong irritant and a common cosmetic allergen (29, 30). College and professional athletes must avoid using cosmetics with chlorphenesin at all costs, otherwise they will fail their drug tests because chlorphenesin breaks down into banned muscle relaxant 4-CPA in the body (31). The U.S. Anti-Doping Agency determined that, “when the team of scientists applied sunscreen to themselves, urine samples contained a 4-CPA level of 1,400 ng/ml after just one use (32).”
A cancer-causing substance on California’s Prop. 65 list (33). This ingredient tests positive for mutagenicity in toxicology tests. Cocamide MEA (and relatedly, triethanolamine and diethanolamine) cause the formation of carcinogenic nitrosamines including N-Ni- trosodiethanolamine (NDELA), the most commonly found nitrosamine in cosmetics (34).
A formaldehyde-releasing cosmetic preservative. Formaldehyde is one of the most documented human carcinogens and it is unsafe at any exposure level. The official classification of formaldehyde as a human carcinogen was made after 26 leading scientists at universities in 10 countries reported their findings to the WHO’s IARC (35). Formaldehyde in cosmetics often exceeds legally accepted limits due to the use of cheaper, less sensitive testing methods, over those that measure both free and bound formaldehyde (36).
A formaldehyde-releasing cosmetic preservative. Formaldehyde is one of the most well documented human carcinogens and it is unsafe at any exposure level. The official classification of formaldehyde as a human carcinogen was made after 26 leading scientists at universities in 10 countries reported their findings to the WHO’s IARC (35). Formaldehyde in cosmetics often exceeds legally accepted limits due to the use of cheaper, less sensitive testing methods, over those that measure both free and bound formaldehyde (36).
Diethylhexyl Phthalate (DHEP)
A carcinogenic chemical use to make perfumes last longer on the skin (37). U.S. Department of Health and Human Services says, “DEHP is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity” and it is also a reproductive toxicant, endocrine toxicant, nephrotoxicant and neurotoxicant (38).
A carcinogen that remains in cosmetic ingredients it yields: polysorbate 20, polysorbate 60, polysorbate 80, phenoxyethanol, SLS and PEG compounds. US DHHS NTP says, “Ethylene oxide is known to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in humans, including epi- demiological studies and studies on mechanisms of carcinogenesis (39).”
Ethylenediaminetetraacetic acid is a chelating agent added to cosmetics for preservativation and foaming performance. Mutagenicity studies have found that “EDTA enhances mutagen-induced aberration frequencies. Furthermore, the chelating agent is able to increase the incidence of meiotic crossing-over” and “EDTA interferes with DNA repair processes that take place after exposure to mutagens (40).”
The secretive “fragrance/parfum” ingredient often includes hidden carcinogens and toxicants including acetaldehyde, nitro-musks and butoxyethanol (41). Companies can claim “fragrance” ingredients are a trade secret, which is protected by Title 21, Code of Federal Regulations (CFR), Part 701.3(a), FDA.gov (42, 43).
Lead, mercury and chromium are mutagenic and carcinogenic contaminants or intentionally added ingredients in cosmetics. Lead is a contaminant in some cosmetic ingredients like chlorphenesin and pigments, with some lipsticks testing at a risky 20 ppm of lead (44). There is no safe level of lead exposure because it is a cumulative toxicant that is stored in the brain, teeth and bones (45).
Mercury is illegally added to some skin-lightening cosmetics to whiten skin, while chromium is intentionally added to some green (chromium oxide), yellow (lead chromate) and lead in (lead chromate oxide) pigments (46).
Homosalate is a genotoxic chemical sunscreen agent that induces oxidative stress in cells, and damages mitochondrial membranes (47, 48). Pregnant women are advised to avoid homosalate because it damages the placental cells that nourish the embryo (48).
Methylisothiazolinone and Methylchloroisothiazolinone
Fatty acids from petroleum that are absorbed through human skin, stored in adipose tissue and not completely excreted. Mineral oil snuck into food and cosmetics has led to mineral oil being the largest contaminant in human tissue (55).
Musk (Synthetic musks have replaced threatened musk deers’ animal musk)
Synthetic nitro-musks, musk ketone, musk ambrette and musk xylene, are carcinogenic (56, 57, 58). Polycyclic musks tonalide and galaxolide interfere with human serum albumin (HSA), which regulates our blood pressure and transports essential compounds in our bloodstream (59).
Octocrylene is a chemical sunscreen agent that causes considerable DNA-damaging free-radical singlet oxygen production, enhances UVA-induced cell damage, and contains carcinogen benzophenone (60, 61, 62).
Oxybenzone is a genotoxic chemical sunscreen agent that induces chromosomal aberrations, passes easily through human skin and accumulates in the bloodstream 339-419 times higher than the FDA limit after a single use (62, 63, 64). Oxybenzone is also a phototoxicant and America’s and Europe’s most common cause of phototoxicity and photoallergic contact dermatitis (PACD) (65, 66).
Parabens are a category of cosmetic preservatives that are genotoxic xenoestrogens: butylparaben, methylparaben, propylparaben and ethylparaben (67). They are absorbed locally and systemically following topical application in cosmetics and persist in human tissue and placenta when they routinely escape the enzymes that break them down (68, 69).
Extensive research has shown that parabens activate mTOR and c-Myc, which cause tumorigenesis (70, 71, 72). Butylparaben induced ‘paraben intoxication’ can be measured following topical application in cosmetics by quantifying pro-inflammatory cytokines and brain oxidative stress biomarkers and methylparaben is stored in human brain hypothalamic tissue (73, 74, 75).
PEG compounds are emulsifiers including PEG-200 dilaurate, PEG-20 glyceryl triisostearate, PEG-10 isostearate and PEG-16 lanolin that contain carcinogens 1,4-dioxane and ethylene oxide (EtO) (76). PEG-400 has the ability to boost the genotoxic effect of trimethylolpropane triacrylate compared to control (77).
Petrolatum, Paraffin and Mineral Oil
Petrolatum, paraffin and mineral oil are skin moisturizers in cosmetics that elicit an immune response in human tissue following topical application and are considered a factor in the development of rheumatoid arthritis (RA) (78, 79). Petrolatum is contaminated with numerous PAHs that are known human carcinogens. “Benzo[a]pyrene (BaP) and dibenzo[a,h]anthracene (DBA), both are classified as the most carcinogenic,” and there is indication that novel PAHs remain in even USP (white petroleum jelly) petrolatum (80).
P-phenylenediamine (PPD), p-aminophenol, m-aminophenol and o-aminophenol, 4-aminoazobenzene
Cosmetic grade phenoxyethanol regularly has too high a concentration of unreacted phenol (carbolic acid) for use in baby products because babies are sensitive to its neurotoxicity in much smaller amounts than adults (83). The EU requires that all phenoxyethanol is pharmaceutical grade with less than 10 ppm phenol under EC 1223/2009 and less than 1% phenoxyethanol per product, but the U.S. does not require this (81). Phenoxyethanol also has residual carcinogen ethylene oxide (EtO) and phenol from manufacturing (84).
Phthalates (in “fragrance” or “parfum” listing, see DHEP entry)
Phthalates are carcinogenic chemicals used to make perfume and hairspray last longer on the skin and hair (37). U.S. Dept of Health and Human Services says, “DEHP is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity” and it is also a reproductive toxicant, endocrine toxicant, nephrotoxicant and neurotoxicant (38).
Polysorbate 20, 60 or 80
Contain unacceptable levels of ethylene oxide, one of the most confirmed human carcinogens (39).
An ingredient in cosmetics and hair care that releases formaldehyde, a confirmed human carcinogen (86).
A highly toxic skin-lightening dihydroxybenzene compound (87). Dermatology has largely abandoned using resorcinol due to its toxicity and causing abnormal thyroid enlargement in even small amounts (88).
Triclosan and Triclocarban
Carcinogenic and toxic antimicrobials that were used in hand soap and other personal care products (91). Triclosan and triclocarban induce breast cell cancer and exposure to carcinogens should be strictly limited because, “More than 85% of breast cancers are sporadic and attributable to long-term exposure to environmental carcinogens and co-carcinogens (92).”
Xylene and Methoxyethanol
National Toxicology Program:
1. Department of Health and Human Services; National Toxicology Program (2014); 1,4-Dioxane; Report on Carcinogens, Fifteenth Edition; https://ntp.niehs.nih.gov/ntp/roc/content/profiles//dioxane.pdf
2. Birkel T.J.; Warner C.R.; Fazio T.; Gas chromatographic determination of 1, 4-dioxane in polysorbate 60 and polysorbate 80; Journal of the Association of Official Analytical Chemists, 1979 Jul 1;62(4):931-6; https://doi.org/10.1093/jaoac/62.4.931
3. Department of Health and Human Services; National Toxicology Program (2014); Acetaldehyde; Report on Carcinogens, Fifteenth Edition; https://ntp.niehs.nih.gov/ntp/roc/content/profiles/acetaldehyde.pdf
4. Mitran E.; Callender T.; Orha B.; Dragnea P.; Botezatu G.; Neurotoxicity associated with occupational exposure to acetone, methyl ethyl ketone, and cyclohexanone; Environmental research, 1997 Apr 1;73(1-2):181-8; https://pubmed.ncbi.nlm.nih.gov/9311545/
5. Opinion of the Scientific Committee on Cosmetic and Non-Food Products Intended for Consumers Concerning Acetonitrile Adopted by the Plenary Session of the SCCNFP, 21 JANUARY 1998; https://ec.europa.eu/health/scientific_committees/consumer_safety/opinions/sccnfp_opinions_97_04/sccp_out14_en.htm
6. Yiu G.; Rapid communications: Antiperspirant induced DNA damage in canine cells by Comet assay; Toxicology mechanisms and methods, 2004 Jan 1;15(1):25-8; https://www.tandfonline.com/doi/abs/10.1080/15376520590890677
7. Pineau A.; Guillard O.; Fauconneau B.; Favreau F.; Marty M.H.; Gaudin A.; Vincent C.M.; Marrauld A.; Marty J.P.; In vitro study of percutaneous absorption of aluminum from antiperspirants through human skin in the Franz™ diffusion cell; Journal of inorganic biochemistry, 2012 May 1;110:21-6; https://www.dr-jetskeultee.nl/jetskeultee/download/common/artikel-aluminium-1.pdf
8. Guillard O.; Fauconneau B.; Olichon D.; Dedieu G.; Deloncle R.; Hyperaluminemia in a woman using an aluminum-containing antiperspirant for 4 years; The American journal of medicine, 2004 Dec 15;117(12):956-9; https://pubmed.ncbi.nlm.nih.gov/15629736/
9. Tolerable Upper Intake Levels for Vitamins and Minerals; Scientific Committee on Food; Scientific Panel on Dietetic Products, Nutrition and Allergies; https://www.efsa.europa.eu/sites/default/files/efsa_rep/blobserver_assets/ndatolerableuil.pdf
10. Department of Health and Human Services; National Toxicology Program (2014); Aminomethyl Propanol; Report on Carcinogens, Fifteenth Edition; Retrieved from https://ntp.niehs.nih.gov/ntp/roc/content/profiles//nitrosamines.pdf
11. Yazar, S.; Assessment of in vitro genotoxic effect of homosalate in cosmetics; https://www.researchgate.net/profile/Selma-Yazar/publication/322887211_Assessment_of_in_vitro_genotoxic_effect_of_homosalate_in_cosmetics/links/5cd26dd392851c4eab8991d3/Assessment-of-in-vitro-genotoxic-effect-of-homosalate-in-cosmetics.pdf
12. Paris, C.; Lhiaubet-Vallet, V.; Jime´nez, O.; Trullas, C.; Miranda, M.; A Blocked Diketo Form of Avobenzone: Photostability, Photosensitizing Properties and Triplet Quenching by a Triazine-derived UVB-filter; Photochemistry and Photobiology, 2009, 85: 178–184; https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1751-1097.2008.00414.x
13. Sayre, R.; Dowdy, J.; Gerwig, A.; Shlelds, W.; Lioyd, R.; Unexpected Photolysis of the Sunscreen Octinoxate in the Presence of the Sunscreen Avobenzone; https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1751-1097.2005.tb00207.x
14. Liu H.; Routley I.; Teichmann K.D.; Toxic endothelial cell destruction from intraocular benzalkonium chloride; Journal of Cataract & Refractive Surgery, 2001 Nov 1;27(11):1746-50; https://www.sciencedirect.com/science/article/abs/pii/S0886335001010677
15. U.S. Department of Health and Human Services; National Toxicology Program (2014); Report on carcinogens, fifteenth edition; Retrieved from ntp.niehs.nih.gov/ntp/roc/content/profiles/butylatedhydroxyanisole.pdf
16. California Environmental Protection Agency, Office of Environmental Health Hazard Assessment. List of chemicals known to the state to cause cancer or reproductive toxicity. Retrieved November 9, 2018, from oehha.ca.gov/proposition-65/proposition-65-list
17. Bauer A.K.; Dwyer-Nield L.D.; Two-stage 3-methylcholanthrene and butylated hydroxytoluene-induced lung carcinogenesis in mice; Methods in Cell Biology, 2021 Jan 1;163:153-73; https://www.sciencedirect.com/science/article/abs/pii/S0091679X20301461
18. Office of Environmental Health Hazard Assessment, July 2011; https://oehha.ca.gov/media/downloads/crnr/101211butylatedhydroxycic.pdf
19. Drozdz K., Wysokinski D., Krupa R., Wozniak K. Bisphenol A-glycidyl methacrylate induces a broad spectrum of DNA damage in human lymphocytes. Arch. Toxicol. 2011;85:1453–1461. https://link.springer.com/content/pdf/10.1007/s00204-010-0593-x.pdf DOI 10.1007/s00204-010-0593-x
20. Audebert M.; Dolo L.; Perdu E.; Cravedi J.P.; Zalko D.; Use of the gammaH2AX assay for assessing the genotoxicity of bisphenol A and bisphenol F in human cell lines; Arch. Toxicol., 2011;85:1463–1473. DOI 10.1007/s00204-011-0721-2 https://www.researchgate.net/profile/Marc-Audebert/publication/51204259_Use_of_the_gH2AX_assay_for_assessing_the_genotoxicity_of_bisphenol_A_and_bisphenol_F_in_human_cell_lines/links/0fcfd511a2a93b3da6000000/Use-of-the-gH2AX-assay-for-assessing-the-genotoxicity-of-bisphenol-A-and-bisphenol-F-in-human-cell-lines.pdf
21. Khan N.G.; Correia J.; Adiga D.; Rai P.S.; Dsouza H.S.; Chakrabarty S.; Kabekkodu S.P.; A comprehensive review on the carcinogenic potential of bisphenol A: clues and evidence; Environmental Science and Pollution Research, 2021 Mar 5:1-21; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8099816/
22. Yang H.; Wang C.; Liao H.; Wang Q.; Activation of GPER by E2 promotes proliferation, invasion and migration of breast cancer cells by regulating the miR‑124/CD151 pathway; Oncology Letters, 2021 Jun 1;21(6):1-9; https://pubmed.ncbi.nlm.nih.gov/33868470/
23. Seachrist D.D.; Bonk K.W.; Ho S.M.; Prins G.S.; Soto A.M.; Keri R.A.; A review of the carcinogenic potential of bisphenol A; Reproductive Toxicology, 2016 Jan 1;59:167-82; https://pubmed.ncbi.nlm.nih.gov/26493093/
24. Hafezi S.A.; Abdel-Rahman W.M.; The endocrine disruptor bisphenol A (BPA) exerts a wide range of effects in carcinogenesis and response to therapy; Current molecular pharmacology, 2019 Aug;12(3):230; https://pubmed.ncbi.nlm.nih.gov/30848227/
25. Pupo M.; Pisano A.; Lappano R.; Santolla M.F.; De Francesco E.M.; Abonante S.; Rosano C.; Maggiolini M.; Bisphenol A induces gene expression changes and proliferative effects through GPER in breast cancer cells and cancer-associated fibroblasts; Environmental health perspectives, 2012 Aug;120(8):1177-82; https://pubmed.ncbi.nlm.nih.gov/22552965/
26. California Office of Environmental Health Hazard Assessment; Bisphenol A (BPA); https://oehha.ca.gov/proposition-65/chemicals/bisphenol-bpa
27. Haufroid V.; Thirion F.; Mertens P.; Buchet JP.; Lison D.; Biological monitoring of workers exposed to low levels of 2-butoxyethanol; International archives of occupational and environmental health, 1997 Sep;70(4):232-6; https://link.springer.com/article/10.1007/s004200050212
28. Tao X.; Li H.; Song S.; Li T.; Xie Z.; Exploring on occupational health risk assessment of 2-butoxyethanol in a printing house; Chinese Journal of Industrial Hygiene and Occupational Diseases, 2019:554-7.; https://pesquisa.bvsalud.org/portal/resource/pt/wpr-805600
29. Wang J.; Liu Y.; Kam W.R.; Li Y.; Sullivan D.A.; Toxicity of the cosmetic preservatives parabens, phenoxyethanol and chlorphenesin on human meibomian gland epithelial cells; Experimental eye research, 2020 Jul 1;196:108057; https://www.sciencedirect.com/science/article/abs/pii/S001448352030316X
30. Andre P.; Haneke E.; Marini L.; Payne C.R.; Allergic risks to cosmetics and hypersensitive skin; InCosmetic Medicine and Surgery, 2017 Jan 27 (pp. 113-120); CRC Press; https://www.taylorfrancis.com/chapters/edit/10.1201/9781315382364-18/allergic-risks-cosmetics-hypersensitive-skin
31. Rubio A.; Görgens C.; Krug O.; Okano M.; Fedoruk M.; Ahrens B.; Geyer H.; Thevis M.; Chromatographic‐mass spectrometric analysis of the urinary metabolite profile of chlorphenesin observed after dermal application of chlorphenesin‐containing sunscreen; Rapid Communications in Mass Spectrometry, 2021 Dec 15;35(21):e9183; https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/rcm.9183
32. King, N.; USADA clears Rob Font after cosmetic product leads to positive test; WADA flaw exposed; MMA Junkie, 2 July 2021; https://mmajunkie.usatoday.com/2021/07/ufc-news-usada-clears-rob-font-tainted-hair-product-lotion
33. Proposition 65; Cocamide Diethanolamine (Cocamide DEA); https://www.p65warnings.ca.gov/fact-sheets/cocamide-diethanolamine-cocamide-dea-coconut-oil-diethanolamine-condensate
34. Khan A.D.; Alam M.N.; Cosmetics and their associated adverse effects: a review; Journal of Applied Pharmaceutical Sciences and Research, 2019 Apr 4:1-6.; https://www.p65warnings.ca.gov/sites/default/files/downloads/factsheets/cocamide_diethanolamine_fact_sheet.pdf
35. IARC Monographs; International Agency for Research on Cancer; World Health Organization; https://monographs.iarc.who.int/wp-content/uploads/2018/06/mono100F-29.pdf
36. Emeis D.; Anker W.; Wittern K.P.; Quantitative 13C NMR spectroscopic studies on the equilibrium of formaldehyde with its releasing cosmetic preservatives; Analytical chemistry, 2007 Mar 1;79(5):2096-100; https://pubs.acs.org/doi/abs/10.1021/ac0619985
37. Rowdhwal, S.S.; Chen, J.; Toxic Effects of Di-2-ethylhexyl Phthalate: An Overview; rview. BioMed research international, 2018 Feb 22;2018; https://doi.org/10.1155/2018/1750368
38. Rowdhwal SS, Chen J. Toxic effects of di-2-ethylhexyl phthalate: an overview; BioMed research international, 2018 Feb 22;2018; https://ntp.niehs.nih.gov/ntp/roc/content/profiles/diethylhexylphthalate.pdf
39. Department of Health and Human Services; National Toxicology Program (2014); Ethylene Oxide; Report on Carcinogens, Fifteenth Edition; https://ntp.niehs.nih.gov/ntp/roc/content/profiles/ethyleneoxide.pdf
40. Heindorff K.; Aurich O.; Michaelis A.; Rieger R.; Genetic toxicology of ethylenediaminetetraacetic acid (EDTA); Mutation Research/Reviews in Genetic Toxicology, 1983 Jun 1;115(2):149-73; https://pubmed.ncbi.nlm.nih.gov/6406880/
41. Gao Y.; Li G.; Qin Y.; Ji Y.; Mai B.; An T.; New theoretical insight into indirect photochemical transformation of fragrance nitro-musks: Mechanisms, eco-toxicity and health effects; Environment international, 2019 Aug 1;129:68-75; https://www.sciencedirect.com/science/article/pii/S0160412019300029
42. U.S. Food & Drug Administration; Fragrances in Cosmetics; https://www.fda.gov/cosmetics/cosmetic-ingredients/fragrances-cosmetics
43. Gervin, G.; You Can Stand Under My Umbrella: Weighing Trade Secret Protection Against the Need for Greater Transparency in Perfume and Fragranced Product Labeling; University of Georgia, School of Law; https://digitalcommons.law.uga.edu/cgi/viewcontent.cgi?referer=https://scholar.google.com/scholar?hl=en&as_sdt=0%2C5&q=fragrance+trade+secret&btnG=&httpsredir=1&article=1299&context=jipl
44. Al-Saleh I.; Al-Enazi S.; Shinwari N.; Assessment of lead in cosmetic products; Regulatory toxicology and pharmacology, 2009 Jul 1;54(2):105-13; https://www.sciencedirect.com/science/article/pii/S0273230009000336
45. Boskabady M.; Marefati N.; Farkhondeh T.; Shakeri F.; Farshbaf A.; Boskabady M.H.; The effect of environmental lead exposure on human health and the contribution of inflammatory mechanisms, a review; Environment international, 2018 Nov 1;120:404-20; https://www.sciencedirect.com/science/article/pii/S0160412018307554
46. Kilic S.; Kilic M.; Soylak M.; The determination of toxic metals in some traditional cosmetic products and health risk assessment; Biological Trace Element Research, 2021 Jun;199(6):2272-7; https://pubmed.ncbi.nlm.nih.gov/32888120/
47. Yazar S.; Kara Ertekin S.; Assessment of the cytotoxicity and genotoxicity of homosalate in MCF‐7.;Journal of cosmetic dermatology, 2020 Jan;19(1):246-52; https://onlinelibrary.wiley.com/doi/pdf/10.1111/jocd.12973
48. Yang C.; Lim W.; Bazer F.W.; Song G.; Homosalate aggravates the invasion of human trophoblast cells as well as regulates intracellular signaling pathways including PI3K/AKT and MAPK pathways; Environmental Pollution, 2018 Dec 1;243:1263-73; https://www.sciencedirect.com/science/article/abs/pii/S0269749118309990
49. Gaskell M.; McLuckie K.I.; Farmer P.B.; Genotoxicity of the benzene metabolites para-benzoquinone and hydroquinone; Chemico-biological interactions, 2005 May 30;153:267-70; https://pubmed.ncbi.nlm.nih.gov/15935826/
50. Zeng M.; Chen S.; Zhang K.; Liang H.; Bao J.; Chen Y.; Zhu S.; Jiang W.; Yang H.; Wei Y.; Guo L.; Epigenetic changes involved in hydroquinone-induced mutations; Toxin Reviews, 2020 Apr 1:1-8; https://www.tandfonline.com/doi/abs/10.1080/15569543.2020.1744660
51. Charlín R.; Barcaui C.B.; Kac B.K.; Soares D.B.; Rabello‐Fonseca R.; Azulay‐Abulafia L.; Hydroquinone‐induced exogenous ochronosis: a report of four cases and usefulness of dermoscopy; International journal of dermatology, 2008 Jan;47(1):19-23; https://pubmed.ncbi.nlm.nih.gov/18173595/
52. Mishra S.N.; Dhurat R.S.; Deshpande D.J.; Nayak C.S.; Diagnostic utility of dermatoscopy in hydroquinone‐induced exogenous ochronosis; International journal of dermatology, 2013 Apr;52(4):413-7; https://pubmed.ncbi.nlm.nih.gov/22348652/
53. He K.; Huang J.; Lagenaur C.F.; Aizenman E.; Methylisothiazolinone, a neurotoxic biocide, disrupts the association of SRC family tyrosine kinases with focal adhesion kinase in developing cortical neurons; Journal of Pharmacology and Experimental Therapeutics, 2006 Jun 1;317(3):1320-9; https://www.semanticscholar.org/paper/Methylisothiazolinone%2C-A-Neurotoxic-Biocide%2C-the-of-He-Huang/b21f42e02f385c62ba345840be98de81cffa0d9d?p2df
54. Lundov M.D.; Opstrup M.S.; Johansen J.D.; Methylisothiazolinone contact allergy–a growing epidemic; Contact dermatitis, 2013 Nov;69(5):271-5; https://pubmed.ncbi.nlm.nih.gov/24117738/
55. Concin N.; Hofstetter G.; Plattner B.; Tomovski C.; Fiselier K.; Gerritzen K.; Fessler S.; Windbichler G.; Zeimet A.; Ulmer H.; Siegl H.; Mineral oil paraffins in human body fat and milk; Food and Chemical Toxicology, 2008 Feb 1;46(2):544-52; https://www.dr-jetskeultee.nl/jetskeultee/download/common/6112014.pdf
56. Emig M.; Reinhardt A.; Mersch-Sundermann V.; A comparative study of five nitro musk compounds for genotoxicity in the SOS chromotest and Salmonella mutagenicity; Toxicology letters, 1996 Jun 1;85(3):151-6; https://pubmed.ncbi.nlm.nih.gov/8644127/
57. Mersch-Sundermann V.; Schneider H.; Freywald C.; Jenter C.; Parzefall W.; Knasmüller S.; Musk ketone enhances benzo (a) pyrene induced mutagenicity in human derived Hep G2 cells; Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2001 Aug 22;495(1-2):89-96; https://pubmed.ncbi.nlm.nih.gov/11448646/
58. Apostolidis S.; Chandra T.; Demirhan I.; Cinatl J.; Doerr H.W.; Chandra A.; Evaluation of carcinogenic potential of two nitro-musk derivatives, musk xylene and musk tibetene in a host-mediated in vivo/in vitro assay system; Anticancer research, 2002 Sep 1;22(5):2657-62; https://pubmed.ncbi.nlm.nih.gov/12529978/
59. Xiang H.; Sun Q.; Wang W.; Li S.; Xiang X.; Li Z.; Liao X.; Li H.; Study of conformational and functional changes caused by binding of environmental pollutant tonalide to human serum albumin; Chemosphere, 2021 May 1;270:129431; https://www.sciencedirect.com/science/article/pii/S0045653520336298
60. Allen J.M.; Gossett C.J.; Allen S.K.; Photochemical formation of singlet molecular oxygen in illuminated aqueous solutions of several commercially available sunscreen active ingredients; Chemical research in toxicology, 1996 Apr 16;9(3):605-9; https://pubs.acs.org/doi/abs/10.1021/tx950197m
61. Hanson K.M.; Gratton E.; Bardeen C.J.; Sunscreen enhancement of UV-induced reactive oxygen species in the skin; Free Radical Biology and Medicine, 2006 Oct 15;41(8):1205-12; https://www.sciencedirect.com/science/article/pii/S0891584906004138
62. Downs C.A.; DiNardo J.C.; Stien D.; Rodrigues A.M.; Lebaron P.; Benzophenone accumulates over time from the degradation of octocrylene in commercial sunscreen products; Chemical Research in Toxicology, 2021 Mar 7;34(4):1046-54; https://pubs.acs.org/doi/10.1021/acs.chemrestox.0c00461
63. Santovito A.; Ruberto S.; Galli G.; Menghi C.; Girotti M.; Cervella P.; Induction of chromosomal aberrations and micronuclei by 2-hydroxy-4-methoxybenzophenone (oxybenzone) in human lymphocytes; Drug and chemical toxicology, 2019 Jul 4;42(4):378-85; https://www.tandfonline.com/doi/abs/10.1080/01480545.2018.1455206
64. Matta M.K.; Florian J.; Zusterzeel R.; Pilli N.R.; Patel V.; Volpe D.A.; Yang Y.; Oh L.; Bashaw E.; Zineh I.; Sanabria C.; Oxybenzone violates FDA absorption limit; Effect of sunscreen application on plasma concentration of sunscreen active ingredients: a randomized clinical trial; Jama, 2020 Jan 21;323(3):256-67; https://jamanetwork.com/journals/jama/article-abstract/2759002
65. DiNardo J.C.; Downs C.A.; Dermatological and environmental toxicological impact of the sunscreen ingredient oxybenzone/benzophenone‐3.; Journal of cosmetic dermatology, 2018 Feb;17(1):15-9; https://pubmed.ncbi.nlm.nih.gov/29086472/
66. Downs C.A.; Kramarsky-Winter E.; Segal R.; Fauth J.; Knutson S.; Bronstein O.; Ciner F.R.; Jeger R.; Lichtenfeld Y.; Woodley C.M.; Pennington P.; Toxicopathological effects of the sunscreen UV filter, oxybenzone (benzophenone-3), on coral planulae and cultured primary cells and its environmental contamination in Hawaii and the US Virgin Islands; Archives of environmental contamination and toxicology, 2016 Feb;70(2):265-88; https://pubmed.ncbi.nlm.nih.gov/26487337/
67. Güzel Bayülken D.; Ayaz Tüylü B.; Sinan H.; Sivas H.; Investigation of genotoxic effects of paraben in cultured human lymphocytes; Drug and chemical toxicology, 2019 Jul 4;42(4):349-56; https://pubmed.ncbi.nlm.nih.gov/29281926/
68. Harvey P.W.; Everett D.J.; Parabens detection in different zones of the human breast: consideration of source and implications of findings; Journal of Applied Toxicology, 2012 Mar 7;32(5):305-309; https://doi.org/10.1002/jat.2743
69. Yang C.; Lim W.; Bazer F.W.; Song G.; Butyl paraben promotes apoptosis in human trophoblast cells through increased oxidative stress‐induced endoplasmic reticulum stress; Environmental toxicology, 2018 Apr;33(4):436-45; https://pubmed.ncbi.nlm.nih.gov/29319206/
70. Fallah Y.; Brundage J.; Allegakoen P.; Shajahan-Haq A.N.; MYC-driven pathways in breast cancer subtypes. Biomolecules. 2017 Sep;7(3):53; https://pubmed.ncbi.nlm.nih.gov/28696357/
71. Pan S.; Yuan C.; Tagmount A.; Rudel R.A.; Ackerman J.M.; Yaswen P.; Vulpe C.D.; Leitman D.C.; Parabens and human epidermal growth factor receptor ligand cross-talk in breast cancer cells; Environmental health perspectives, 2016 May;124(5):563-9; https://ehp.niehs.nih.gov/doi/10.1289/ehp.1409200
72. Darbre P.D.l Harvey P.W.; Parabens can enable hallmarks and characteristics of cancer in human breast epithelial cells: a review of the literature with reference to new exposure data and regulatory status; Journal of Applied Toxicology, 2014 Sep;34(9):925-38; https://pubmed.ncbi.nlm.nih.gov/25047802/
73. Van der Meer T.P.; Artacho-Cordón F.; Swaab D.F.; Struik D.; Makris K.C.; Wolffenbuttel B.H.; Frederiksen H.; Vliet-Ostaptchouk V.; Jana V.; Distribution of non-persistent endocrine disruptors in two different regions of the human brain; International journal of environmental research and public health, 2017 Sep;14(9):1059; https://pubmed.ncbi.nlm.nih.gov/28902174/
74. Hegazy H.G.; Ali E.H.; Elgoly A.H.; Interplay between pro-inflammatory cytokines and brain oxidative stress biomarkers: evidence of parallels between butyl paraben intoxication and the valproic acid brain physiopathology; Cytokine, 2015 Feb 1;71(2):173-80; https://pubmed.ncbi.nlm.nih.gov/25461396/
75. Jiang Y.; Zhao H.; Xia W.; Li Y.; Liu H.; Hao K.; Chen J.; Sun X.; Liu W.; Li J.; Peng Y.; Prenatal exposure to benzophenones, parabens and triclosan and neurocognitive development at 2 years; Environment international, 2019 May 1;126:413-21; https://pubmed.ncbi.nlm.nih.gov/30831476/
76. Khan A.D.; Alam M.N.; Cosmetics and their associated adverse effects: a review; Journal of Applied Pharmaceutical Sciences and Research. 2019 Apr 4:1-6; https://www.researchgate.net/publication/332243856_COSMETICS_AND_THEIR_ASSOCIATED_ADVERSE_EFFECTS_A_REVIEW
77. Le Hegarat L.; Huet S.; Pasquier E.; Charles S.; Impact of solvents on the in vitro genotoxicity of TMPTA in human HepG2 cells; Toxicology in Vitro, 2020 Dec 1;69:105003; https://doi.org/10.1016/j.tiv.2020.105003
78. Whitehouse M.; Oily adjuvants and autoimmunity: now time for reconsideration?; Lupus, 2012 Feb;21(2):217-22; https://pubmed.ncbi.nlm.nih.gov/22235056/
79. Sverdrup B.; Klareskog L.; Kleinau S.; Common commercial cosmetic products induce arthritis in the DA rat; Environmental health perspectives, 1998 Jan;106(1):27-32; https://pubmed.ncbi.nlm.nih.gov/9417771/
80. Wang S.W.; Hsu K.H.; Huang S.C.; Tseng S.H.; Wang D.Y.; Cheng H.F.; Determination of polycyclic aromatic hydrocarbons (PAHs) in cosmetic products by gas chromatography-tandem mass spectrometry. journal of food and drug analysis, 2019 Jul 1;27(3):815-24; https://pubmed.ncbi.nlm.nih.gov/31324297/
81. Balakrishnan V.K.; Shirin S.; Aman A.M.; de Solla S.R.; Mathieu-Denoncourt J.; Langlois V.S.; Genotoxic and carcinogenic products arising from reductive transformations of the azo dye, Disperse Yellow 7; Chemosphere, 2016 Mar 1;146:206-15; https://www.sciencedirect.com/science/article/abs/pii/S0045653515304501
82. Khandavilli U.B.; Keshavarz L.; Skořepová E.; Steendam R.R.; Frawley P.J.; Organic Salts of Pharmaceutical Impurity p-Aminophenol; Molecules, 2020 Jan;25(8):1910; https://pubmed.ncbi.nlm.nih.gov/32326160/
83. D’Souza R.S.; Warner N..S.; Phenol Nerve Block. StatPearls [Internet], 2021 Jul 18. https://www.ncbi.nlm.nih.gov/books/NBK525978/
84. Opinion on Phenoxyethanol; Scientific Committee on Consumer Safety, 6 October 2016; https://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_195.pdf
85. Miller S.A.; Bann B.; Thrower R.D.; 716; The reaction between phenol and ethylene oxide; Journal of the Chemical Society (Resumed), 1950:3623-8; https://pubs.rsc.org/en/content/articlelanding/1950/jr/jr9500003623
86. De Groot A.C.; Veenstra M.; Formaldehyde‐releasers in cosmetics in the USA and in Europe; Contact Dermatitis, 2010 Apr;62(4):221-4; https://pubmed.ncbi.nlm.nih.gov/20236159/
87. Zhao J.; Biodegradation of dihydroxybenzenes (hydroquinone, catechol and resorcinol) by granules enriched with phenol in an aerobic granular sequencing batch reactor; Cornell University Theses, 2017; https://www.proquest.com/openview/008f0fc89a088184e7b6b4453c4d9db2/1.pdf?pq-origsite=gscholar&cbl=18750&diss=y
88. Mikolajczyk T.; Luba M.; Pierozynski B.; Kowalski I.M.; Wiczkowski W.; The Influence of Solution pH on the Kinetics of Resorcinol Electrooxidation (Degradation) on Polycrystalline Platinum; Molecules, 2019 Jan;24(12):2309; https://www.mdpi.com/1420-3049/24/12/2309/htm
89. Moro A.M.; Brucker N.; Charão M.; Bulcão R.; Freitas F.; Baierle M.; Nascimento S.; Valentini J.; Cassini C.; Salvador M.; Linden R.; Evaluation of genotoxicity and oxidative damage in painters exposed to low levels of toluene; Mutation research/genetic toxicology and environmental mutagenesis, 2012 Jul 4;746(1):42-8. https://www.sciencedirect.com/science/article/pii/S1383571812000617
90. McMichael A.J.; Carcinogenicity of benzene, toluene and xylene: epidemiological and experimental evidence; IARC scientific publications, 1988 Jan 1(85):3-18; https://pubmed.ncbi.nlm.nih.gov/3053447/
91. Zhang H.; Shao X.; Zhao H.; Li X.; Wei J.; Yang C.; Cai Z.; Integration of metabolomics and lipidomics reveals metabolic mechanisms of triclosan-induced toxicity in human hepatocytes; Environmental science & technology, 2019 Apr 9;53(9):5406-15; https://pubs.acs.org/doi/abs/10.1021/acs.est.8b07281
92. Sood S.; Choudhary S.; Wang H.C.; Induction of human breast cell carcinogenesis by triclocarban and intervention by curcumin; Biochemical and biophysical research communications. 2013 Sep 6;438(4):600-6; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3889154/
93. Methoxyethanol: https://www.who.int/ipcs/publications/cicad/methoxyethanol.pdf